bioinformatics chat

B cell maturation and class switching with Hamish King (#58)

March 31, 2021

In this episode, we learn about B cell maturation and class switching from Hamish King. Hamish recently published a paper on this subject in Science Immunology, where he and his coauthors analyzed gene expression and antibody repertoire data from human tonsils. In the episode Hamish talks about some of the interesting B cell states he uncovered and shares his thoughts on questions such as «When does a B cell decide to class-switch?» and «Why is the antibody isotype correlated with its affinity?»


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Music: Eric Skiff — Come and Find Me (modified, licensed under CC BY 4.0).