bioinformatics chat

3D genome organization and GRiNCH with Da-Inn Erika Lee (#61)

June 23, 2021

In this episode, Jacob Schreiber interviews Da-Inn Erika Lee about data and computational methods for making sense of 3D genome structure. They begin their discussion by talking about 3D genome structure at a high level and the challenges in working with such data. Then, they discuss a method recently developed by Erika, named GRiNCH, that mines this data to identify spans of the genome that cluster together in 3D space and potentially help control gene regulation.

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Music: Eric Skiff — Come and Find Me (modified, licensed under CC BY 4.0).