Phylogenetic inference from raw reads and Read2Tree with David Dylus (#68)

August 28, 2023

In this episode, David Dylus talks about Read2Tree, a tool that builds alignment matrices and phylogenetic trees from raw sequencing reads. By leveraging the database of orthologous genes called OMA, Read2Tree bypasses traditional, time-consuming steps such as genome assembly, annotation and all-versus-all sequence comparisons.

Links:

• Inference of phylogenetic trees directly from raw sequencing reads using Read2Tree (David Dylus, Adrian Altenhoff, Sina Majidian, Fritz J. Sedlazeck, Christophe Dessimoz)
• Background story
• Read2Tree on GitHub
• OMA browser
• The Guardian’s podcast about Victoria Amelina and Volodymyr Vakulenko

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