bioinformatics chat

The role of the DNA shape in transcription factor binding with Hassan Samee (#35)

July 26, 2019

Even though the double-stranded DNA has the famous regular helical shape, there are small variations in the geometry of the helix depending on what exact nucleotides its made of at that position.

In this episode of the bioinformatics chat, Hassan Samee talks about the role the DNA shape plays in recognition of the DNA by DNA-binding proteins, such as transcription factors. Hassan also explains how his algorithm, ShapeMF, can deduce the DNA shape motifs from the ChIP-seq data.


Music: Eric Skiff — Come and Find Me (modified, licensed under CC BY 4.0).

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